1897: Den tyske kjemikeren Felix Hoffmann i firmaet Bayer fremstiller det smertestillende legemiddelet acetylsalisylsyre. Utgangsstoffet salisylsyre hadde imidlertid blitt brukt i årtusener i folkemedisinen i ekstrakter fra blant annet pilbark og seljebark.I enda mer alvorlige tilfeller av isjias kan male oppleve at det blir vanskelig å late vann

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